Clinical and laboratory factors associated with negative oral food challenges
نویسندگان
چکیده
Children with food-specific IgE (FSIgE) ≤2 kUa/L to milk, egg, or peanut (or ≤5kUa/L to peanut without history of previous reaction) are appropriate candidates for oral food challenge (OFC) to investigate resolution of food allergy, because these FSIgE cutoffs are associated with ∼50% likelihood of negative OFC. This study was designed to identify characteristics of children undergoing OFC, based on these FSIgE levels, who are most likely to show negative OFC. We collected demographics, severity of previous reaction, history of atopic diseases, total IgE and FSIgE values, and skin tests results on children who underwent OFCs to milk, egg, or peanut, based on the recommended FSIgE cutoffs. We identified independent factors associated with negative OFCs. Four hundred forty-four OFCs met our inclusion criteria. The proportions of negative OFCs performed based on FSIgE cutoffs alone were 58, 42, and 63% to milk, egg, and peanuts, respectively. Regression models identified independent factors associated with negative OFCs: lower FSIgE levels (all three foods), higher total IgE (milk), consumption of baked egg products (egg), and non-Caucasian race (eggs and peanuts). Combinations of these factors identified subgroups of children with proportions of negative OFCs of 83, 75, and 75% for milk, eggs, and peanuts, respectively. Combinations of clinical and laboratory elements, together with FSIgE values, might identify more children who are likely to have negative OFCs compared with current recommendations using FSIgE values alone. Once validated in a different population, these factors might be used for selection of patients who are most likely to show negative OFCs.
منابع مشابه
Clinical Protests Food Allergy in Children
The best recognized intestinal manifestation of food allergy is food allergic (food-sensitive) enteropathy. The feature of enteropathy may include lymphocyte and plasma cell infiltration, epithelial abnormality, or crypt hyperplastic villous atrophy, and impairing absorption, enterophaty continues while the food remains in the diet, remitting on an exclusion diet, and usually recurring on food ...
متن کاملComparison of Burning Mouth Syndrome Prevalence and its Related Factors between Menopausal and Non-Menopausal Women
Introduction: Burning mouth syndrome (BMS) is defined as burning and pain in the oral mucosa usually without any clinical and laboratory findings. It has a negative effect on patients' quality of life and can be a significant health problem. The aim of this study was to identify major risk factors associated with BMS in menopausal and non-menopausal women at dental clinics of Gorgan, Iran. Meth...
متن کاملعوارض شایع بالینی و آزمایشگاهی ایزوترهتینوئین خوراکی در مبتلایان به آکنهی ندولوکیستیک
Background and Aim: Oral isotretinoin is the only drug that is effective on almost all factors involved in the pathogenesis of acne. Although several studies have been conducted on side effects of this drug, few studies have been conducted on Iranian patients. The aim of this study was to evaluate common clinical and laboratory side effects of this drug in patients with nodulo-cystic acne in Ma...
متن کاملOptimization and development of insulin nanoparticles by new thiolated chitosan derivative with ionic gelation method using a model-based methodology
Insulin therapy has been the best choice for the clinical management of diabetes mellitus. The current insulin therapy is via subcutaneous injection, which often fails to mimic the glucose homeostasis that occurs in normal individuals. Oral delivery is the most convenient administration route. However, insulin cannot be well absorbed orally because of its rapid enzymatic degradation in the gast...
متن کاملDemographics Factors Associated with Housewives\' Attitude towards Transgenic Food Products in Yazd
Background: In the last two decades, genetic engineering has led to the production of genetically modified or transgenic products in the world using the modern biotechnology. However, accepting such products by consumers is still in doubt with respect to their negative effects on the environment and human health. Thus, the present study aimed to evaluate the attitude of housewives in Yazd towar...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 33 شماره
صفحات -
تاریخ انتشار 2012